6.  HEALTH

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H1  Weeklong Improved Colour Contrasts Sensitivity after Single 670nm Exposures Associated with
    Enhanced Mitochondrial Function, 'A 3-minute exposure at 8mW/cm² of 670nm dark red light to
    the eyes between 8am and 9am improves colour cone photoreceptor function in aged subjects to levels
    commonly found in much younger individuals and can be sustained for up to a week',
    H.Shinhmar,C.Hogg,M.Neveu&G.Jeffery 
    Scientific Reports Vol 11, Article number: 22872 (2021), 24-Nov-21
    https://www.nature.com/articles/s41598-021-02311-1
    Originating paper:

    Optically Improved Mitochondrial Function Redeems Aged Human Visual Decline,

    H.Shinhmar,M.Grewal,S.Sivaprasad,C.Hogg,V.Chong,M.Neveu,G.Jeffery,
    The Journals of Gerontology: Series A, Vol 75, Iss 9, September 2020, Pages e49-e52, 29-Jun-20
    https://doi.org/10.1093/gerona/glaa155
    https://www.researchgate.net/publication/342531647
 

H2  Photobiomodulation for the Management of Alopecia: mechanisms of action, patient selection and
    perspectives, Defines LLLT effect on hair regrowth; shows illustrations of follicle structure and
    alternative LLLT treatment devices together with extensive investigations of wavelength efficacy.
    M.Hamblin, Clin Cosmet Investig Dermatol. 2019;12:669–678. 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737896/

H3  A Systematic Review and Meta-analysis of Randomized Controlled Trials of United States Food and
    Drug Administration-Approved, Home-use, Low-Level Light/Laser Therapy Devices for Pattern Hair
    Loss: Device Design and Technology, 'absorption peak at 660nm 31 of CCO',
    S.Lueangarun, P.Visutjindaporn, Y.Parcharoen, P.Jamparuang, T.Tempark,
    J Clin Aesthet Dermatol. 2021 Nov; 14(11): E64-E75
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675345/

H4  Photobiomodulation: Lasers vs. Light Emitting Diodes?,
    Lists all research to date using light to affect medical conditions.
    V.Heiskanen, M.Hamblin, Photochem Photobiol Sci. 2018;17(8):1003–1017 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091542/

​

H5  Tea Tree Oil versus Chlorhexidine Mouthwash in Treatment of Gingivitis:
    A Pilot Randomized, Double Blinded Clinical Trial,
    Although not stated explicitly in the conclusion, it is evident from the 'before' and 'after'

    results tables that significant dental pocket reduction was achieved. This excellent paper also

    describes in detail how to administer a safe dosage of Tea Tree oil for pocket reduction.
    F.Ripari,A.Cera,M.Freda,G.Zumbo,F.Zara,I.Vozza,
    Eur J Dent. 2020 Feb;14(1):55-62. doi: 10.1055/s-0040-1703999. Epub 2020 Mar 13,
    PMID: 32168532 PMCID: PMC7069753 DOI: 10.1055/s-0040-1703999

    https://pubmed.ncbi.nlm.nih.gov/32168532/

​

H6  Comparative evaluation of efficacy of topical and intra-sulcular application of
    Co-enzyme Q10 in the non-surgical treatment of periodontal diseases,
    'There was a significant improvement in the pocket depth in all the studies including the
     intrasulcular application alone as well as the application of coenzyme Q both topically and
     intrasulcularly', P.Dahiya,A.Malhotra,A.Pajnoo,R.Gupta,R.Kamal,
    J Indian Soc Periodontal. 2022 Nov-Dec; 26(6): 533-538, Pub online 2022 Nov 14.
    PMCID: PMC9793934, PMID: 36582958, DOI: 10.4103/jisp.jisp_542_21
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793934/

​

H7  A Comparative Evaluation of Topical and Intrasulcular Application of Coenzyme Q10 (Perio Q TM) Gel      in Chronic Periodontitis Patients: A Clinical Study,
    'There was a significant decrease in the probing pocket depth in...(test groups) at the end of the
     4th week compared with...(control group)'
    S.Sale,H.Parvez,R.Yeltiwar,G.Vivekanandan,

    Journal of Indian Society of Periodontology 18(4):461-5, July 2014,

    DOI:10.4103/0972-124X.138690

    https://pubmed.ncbi.nlm.nih.gov/25210260/
 

H8  Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving
    Periodontal Health. This paper suggests purely supplemental Co-QC10 does not appear to reduce
    pocket depth, but it does reduce oral inflammation. S.Manthena,M.Rao,L.Penubolu,M.Putcha,A.Harsha,
    J Clin Diagn Res. 2015 Aug; 9(8): ZC26-ZC28, Pub online 2015 Aug 1,
    PMCID: PMC4576635, PMID: 26436041, DOI 10.7860/JCDR/2015/13486.6291

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576635/

​

H9  Aloe Vera: Nature's Soothing Healer to Periodontal Disease,
    'The study exhibited significant decrease in pocket depth...Aloe vera also contains vitamins A, C,
     E, B 12, folic acid. Vitamin C, which is involved in collagen synthesis, increases concentration
     of oxygen at the wound site because of dilation of blood vessels. Aloe vera penetrates and
     dilates capillaries going to an injured site, which improves healing.'
    G.Bhat,P.Kudva,V.Dodwad, J Indian Soc Periodontol. 2011 Jul-Sep; 15(3): 205-209.
    PMCID: PMC3200013, PMID: 22028505, DOI: 10.4103/0972-124X.85661
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200013/

​

H10 Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and
    Trial Sequential Analysis, 'We evaluated the efficacy of LLLT in patients with tinnitus by
    meta-analysis. The results showed no favorable effect of LLLT, regardless of the measurement
    method and technical parameters.'
    C.Chen,C.Huang,C.Chang,Y.Cheng,
    Brain Sci. 2020, 10, 931; doi:10.3390/brainsci10120931, Dec 02-Dec-20
    PMID: 33276501, PMCID: PMC7761002, DOI: 10.3390/brainsci10120931

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761002/pdf/brainsci-10-00931.pdf

​

H11 Combined Central and Peripheral Stimulation for Treatment of Chronic Tinnitus: a Randomized Pilot

    Study, 'We found that combined stimulation was effective in tinnitus treatment. This effect

    remained for 4 weeks after the end of the treatment. However, each of rTMS and LLLT alone had no

    significant effect.''...this is the first study to combine peripheral LLLT and central rTMS
    [Transcranial Magnetic Stimulation] for the treatment of chronic tinnitus. We found that a
    combination of both types of neural stimulations is a much more powerful non-invasive and safe
    method of treatment compared with the use of either stimulation alone.'
    M.Thabit,N.Fouad,B.Shahat,M.oussif,
    Neurorehabilitation and Neural Repair, Vol.29 Iss3, March/April 2015, PP 224-233, Epub 15-Jul-14,

    PMID: 25030898, DOI: 10.1177/1545968314542616

    https://journals.sagepub.com/doi/epub/10.1177/1545968314542616

H12 The Effect of Low-Level Laser Therapy on Hearing,

    '532nm & 635nm','No statistically significant effect of LLLT on auditory function was found.'
    S.Goodman,R.Bentler,A.Dittberner,I.Mertes,
    Dept of Communication Sciences & Disorders,University of Iowa, USA, 27-Mar-13

    ISRN Otolaryngology Volume 2013, Article ID 916370, 9 pages
    PMID: 24024040, PMCID: PMC3658388, DOI: 10.1155/2013/916370
    https://downloads.hindawi.com/archive/2013/916370.pdf

​

H13 The Effect of Photobiomodulation on Hearing Loss: A Systematic Review,
    Y.Nikookam,N.Zia,A.Lotfallah,J.Muzaffar1,J.Davis-Manders,P.Kullar,M.Smith,

     17 studies compared, 532nm, 635nm, 808nm, 810nm, 830nm, 908nm from 4 to 60 minutes over 5-28 days.

     Hearing outcomes following PBMT appear to be superior to no PBMT for subjects with

     hearing loss.''almost all studies to date have been conducted on animal models with only one
     conducted on human subjects','Outcomes improved significantly when wavelengths within the range
     of 800–830nm were used, and with greater duration of PBMT exposure.','NAC [N-acetylcysteine] may
     have a role in accelerating hearing improvement with PBMT [But NAC is banned]'.
    G.Bale,P.Boyle,R.Irving,D.Jiang,M.Bance,
    Clin Otolaryngol, 26-Oct-23
    PMID: 37885344 DOI: 10.1111/coa.14113 

    https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14113

H14 Low-Level Laser Therapy for Prevention of Noise-Induced Hearing Loss in Rats,
    '...rats were exposed to intense noise and their right ears were irradiated with an 808nm diode
    laser at an output power density of 110 or 165mW/cm² for a 30min period for 5 consecutive days.
    Measurement of the auditory brainstem response revealed an accelerated recovery of auditory
    function in the groups treated with LLLT compared with the non-treatment'

    A.Tamura,T.Matsunobu,K.Mizutari,K.Niwa,T.Kurioka,S.Kawauchi,
    Neurosci Lett. 2015;595:81-6  19-Mar-15,
    PMID: 25797186, DOI: 10.1016/j.neulet.2015.03.031

    https://www.sciencedirect.com/science/article/abs/pii/S0304394015002244?via%3Dihub

H15 Multiple roles of cytochrome c oxidase in mammalian cells under action of red and IR-A radiation,
    Includes an absorption graph for CCO showing the absolute peak of 760nm for 'relatively reduced
    CuB chromophore of [CCO]'. Other peaks are shown at 620nm, 680nm and 820nm. 

    T.Karu, Life Vol. 62, Iss 8, Pages: spcone, 573-645, August 2010, 28-Jul-10,
    DOI 10.1002/iub.359 Citations: 258
    https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.359
 

H16 Oral Consumption of α-Glucosyl-Hesperidin Could Prevent Lens Hardening, Which Causes Presbyopia,
    'Eye drops...for the treatment of presbyopia. However, the concentration of drugs reaching the lens
    are known to be very low as the lens is covered by the cornea and aqueous humour. Therefore, we
    reasoned that oral consumption of compounds that possess anti-presbyopia effects would be the
    optimum approach.','we previously reported that oral consumption of G-Hsd delayed the onset
    of cataract induced by sodium selenite [5]. So, we hypothesized that G-Hed could prevent
   lens sclerosis, and here we show that lens elasticity was maintained by G-Hsd treatment under
    the same experimental conditions'

    O.Nakazawa,M.Aoki,Y.Doki,N.Morishita,S.Endo,N.Nagai,M.Funakoshi-Tago,H.Tamura,
    Biochemistry and Biophysics Reports Volume 25, March 2021, 10088

    https://www.sciencedirect.com/science/article/pii/S2405580820301953
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773531/pdf/main.pdf

H17 Flower Pollen Extract and its Effect on the Urinary Tract; A Critical Review of Graminex Flower

    pollen extract for Symptomatic Relief of Lower Urinary Tract Symptoms (LUTS) in Men,
    W.Chambliss, University of Mississippi, University, Ms. 38677, 12-JAN-03
https://www.semanticscholar.org/paper/Flower-Pollen-Extract-and-its-Effect-on-the-Urinary-Chambliss/4c1145f7311db44f87ff94e2893ca8ad53015273​

​

H18 Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer
    cells'These findings indicate that flavonoids from blueberry possess the ability to effectively
    decrease MMP activity, which may decrease overall ECM degradation. This ability may be important
    in controlling tumor metastasis formation.'
     M.Matchett,S.Mackinnon, NRC Canada; M.Sweeney, University of Prince Edward Island,
     K.Gottschall-Pass, University of Prince Edward Island
     Biochemistry and Cell Biology 83(5):637-43, DOI:10.1139/o05-063

 https://www.researchgate.net/publication/7531307_Blueberry_flavonoids_inhibit_matrix_metalloproteinase_activity_in_DU145_human_prostate_cancer_cells

​

H19 Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

    S.Pu,Ya.Huang,Chi.Pu,Y.Kang,K.Hoang,K.Chen,C.Chen,
    Nutrients 2023 Apr 26;15(9):2080m PMID: 37432180 PMCID: PMC10180699 DOI: 10.3390/nu15092080

    https://pubmed.ncbi.nlm.nih.gov/37432180/

​

H20 Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration,

    G.Bamini,L.Gerald,K.Annette,F.Victoria,J.Nichole,L.Joshua,H.Jonathan,M.Paul,

    Various Universities, Australia, The American Journal of Clinical Nutrition,

    Volume 108, Issue 2, August 2018, Pages 381-387

    https://www.sciencedirect.com/science/article/pii/S0002916522029355?via%3Dihub

    'Researchers in Australia followed 2856 people over 15 years, recorded their food intake and
    calculated flavonoid consumption. They found that people who ate more foods containing flavonoids
    were 24% less likely to develop macular degeneration. In particular, those who ate more than one
    serving (one cup) of oranges a day, which are high in flavonoids, were 58% less likely to develop
    any macular degeneration. What’s even more interesting is that people eating more than one serving
    of oranges a week were 92% less likely to develop macular degeneration.'
   https://www.research.colostate.edu/healthyagingcenter/2019/01/31/an-orange-a-day-could-help-your-eyes/#:~:text=The%20New%20Findings&text=They%20found%20that%20people%20who,to%20develop%20any%20macular%20degeneration